ACE-031

Description

ACE-031 peptide, also known as ActRIIB-IgG1 peptide, appears to be a myostatin inhibitor. In terms of structure, it is a fusion compound consisting of the activin receptor type IIB (ACV2RB) and recombinant immunoglobulin IgG1 FC, which is a form of antibody.(1) Research suggests that this soluble peptide may block the action of circulating myostatin to potentially prevent myostatin from apparently inhibiting the native ACV2RB receptors and thus reducing muscle growth. Myostatin, also known as growth and differentiation factor 8 (GDF8), apparently may be blocked by certain substances termed inhibitors. These inhibitors may target the actions of naturally occurring myostatin, a possible negative regulator of muscle growth primarily found in skeletal muscle tissues. Interestingly, myostatin seemingly has no impact on cardiac or smooth muscle tissues. The discovery of myos